UNDER CONSTRUCTION

During early embryonic development, cells have to make two things happen at the same time: they need to divide rapidly to increase the number of cells, while also changing their identity and organisation to build an embryo. One of the central signalling pathways controlling this transition…

During early embryonic development, cells need to coordinate two fundamental processes: deciding what they will become and organising themselves into tissues. These processes have to happen in the right order and at the right time. But how does an embryo coordinate changes in cell identity with…

Embryonic development is usually a continuous process. After fertilisation, the embryo progresses through a series of developmental stages until it implants in the uterus and continues to grow. But in some mammals, embryos have evolved a remarkable ability to pause development and wait. This state is…

During early embryonic development, the cells that will eventually form the placenta undergo a remarkable transformation. A small population of cells at the embryonic pole of the blastocyst gives rise to the trophoblast stem-cell compartment, which subsequently expands and develops into the extra-embryonic tissues that support…

Early embryonic development is often described as a process in which cells progressively make increasingly irreversible decisions about their identity. But in the very early embryo, cells are remarkably flexible. They can adapt to changes in their environment, compensate for differences in cell number or position,…

The early mouse embryo begins as a remarkably simple structure: a small group of pluripotent epiblast cells. Yet within a short period of time, these cells undergo a dramatic transformation. They change their developmental state, become polarised and reorganise into an epithelial tissue that will provide…

Pluripotency is usually thought of as a property of cell identity: pluripotent cells have the ability to give rise to many different cell types. But being pluripotent also means that a cell has to maintain a particular physical and metabolic state. We wanted to understand how…

Implantation is one of the most remarkable transitions in early pregnancy. The embryo has to attach to the uterus, invade the maternal tissue and establish connections with the mother’s blood supply. Yet many of the earliest events at this interface remain difficult to observe because the…

Early embryonic development requires a remarkable change in cellular activity. Before implantation, the mouse embryo is relatively metabolically quiet. After implantation, this changes dramatically: the epiblast begins to proliferate rapidly, reorganises into an epithelial structure and undergoes the morphogenetic transformations that build the foundation of the…

How does a simple ball of cells transform into an organised embryo? Around the time of implantation, the mouse embryo undergoes one of the most dramatic transformations in early development. The blastocyst, which contains a hollow cavity surrounded by several cell populations, begins to reorganise into…

What happens when an embryo stops developing? At first, the answer might seem straightforward: development simply comes to a halt. But embryonic diapause — a natural state in which development is temporarily suspended — is much more interesting than that. During diapause, the mouse embryo remains…

The placenta is essential for embryonic development, yet studying how individual genes control its formation has been surprisingly difficult. The reason is simple: the placenta and the embryo come from different cell lineages, but most of the genetic tools we use in mice are designed to…